Okay, I am having a real problem here with your study since CBD is not something outside of the Cannabis chemistry. THC isn't the bad guy, and THC is the CARRIER (not my words but Drs Ethan Russo and Raphael Mechoulam and Their team in Tel Aviv findings) that allows CBD whose molecular structure is TOO Large to penetrate the ECS alone. Their findings show that if you want CBD as a supplement into your Endocannabinoid system you have to have a carrier, whether it be THC or other various other secondary chemicals found in the Cannabis plant to insure the CBD is being transferred into the ECS. So no, CBD isn't "special" in the fact that it is part of the ECS! The whole of the plant has over 450 chemicals in it that induces the isolate CBD to be able to be used by the ECS. Please learn this! Yes, like Grapefruit and other Enzyme P450 antagonist, Cannabis needs special care when being used with other drugs, and in some cases cannabis use orally (or smoked) needs to be stopped during panel series of steroids, etc to avoid serious side effects including kidney damage, etc:
"CBD and other cannabinoids are metabolized extensively by the CYP450 system, and also inhibit many of these enzymes, potentially leading to variable serum levels of other medications, as well as variable levels of cannabinoids when other medications modify the system." There's problems in steroidal use causing increase potency as well as duration of the medication as ONE example.
Putting it in very simple English: Cannabis can cause other drugs you are taken to be stronger and to last longer in the system. If you are taken a sedative (like Clonopin can be, opioids, etc ), the effects of your drugs can be dangerous because the dosage now has been exponentially increased and can cause severe respiration problems (slowing of the heart and lungs to the point you need emergency care). With other drug interactions with P450 issues can include liver damage.
With blood thinners it's a huge issue: From the NIH: "Initiation of cytochrome P-450 (CYP)-inducing anticonvulsant medications during warfarin therapy may decrease anticoagulant effect and necessitate frequent warfarin dose adjustments to maintain therapeutic response measured by the international normalized ratio (INR) ."
Topical cremes that have CBD with some THC involvement, is just not understood well enough. They want to cite the fact that it is dermal so therefore it's not being absorbed into the blood stream, but that does not help us to understand drug interactions that could be dangerous. Citing Harvard School of Medicine that although the topical can involve the liver, so little of us is being utilized, that they THINK it is safer…frankly, they don't know. By looking at Pro Cannabis sites that involve Tel Aviv studies would give you a better idea of what is safe and useable, over hype.
Personally having studied this stuff ad nauseam for my own needs, I found that I would be extremely concerned when taking cannabis of any stripe with steroids, blood thinners, Antidepressants, or sedatives simply because the impact can be seriously harmful. And I am a PRO CANNABIS user.
If you need further guidelines i would suggest a few places to ask your questions: Access for Safe Cannabis Foundation, Realm of Caring (for Dravet's and Cancer patients), Project CBD, the database Leafly, Hemp Round Table (lobbyist group), NORML, for clearer understanding of Cannabis. J Aviarm out of Israel, might give you better leads. All I know is this: Cannabis is a powerful herbal plant. Plants of any kind interact with other allopathic drugs. Taking any herbal formulae needs to be understood that it is medicinal; cannabis is no exception to the rule here. Finding the right information is crucial: While I normally do not suggest Healthline in general, this seems to be the simplest answer to the problem: https://www.healthline.com/health/cbd-and-drug-interactions-what-you-need-to-know#interactions
This link explains Enzyme 450 also with using Grapefruit and other citrus interactions with medication.
Thanks for the video; I am a heart patient, on statins and Toprol XL, but am also on Clonopin, but have been approved for CBD (MMJ). After viewing your video, I am very concerned about the drug interactions with a CBD product.
I just had a seizure Jan 1 , I have seizure medication but when I asked my primary if I can take CBD he said yes . So your saying it can react with my medication ?
What's so hard about simply listing the drugs not to be used with CBD?
Okay, I am having a real problem here with your study since CBD is not something outside of the Cannabis chemistry. THC isn't the bad guy, and THC is the CARRIER (not my words but Drs Ethan Russo and Raphael Mechoulam and Their team in Tel Aviv findings) that allows CBD whose molecular structure is TOO Large to penetrate the ECS alone. Their findings show that if you want CBD as a supplement into your Endocannabinoid system you have to have a carrier, whether it be THC or other various other secondary chemicals found in the Cannabis plant to insure the CBD is being transferred into the ECS. So no, CBD isn't "special" in the fact that it is part of the ECS! The whole of the plant has over 450 chemicals in it that induces the isolate CBD to be able to be used by the ECS. Please learn this! Yes, like Grapefruit and other Enzyme P450 antagonist, Cannabis needs special care when being used with other drugs, and in some cases cannabis use orally (or smoked) needs to be stopped during panel series of steroids, etc to avoid serious side effects including kidney damage, etc:
"CBD and other cannabinoids are metabolized extensively by the CYP450 system, and also inhibit many of these enzymes, potentially leading to variable serum levels of other medications, as well as variable levels of cannabinoids when other medications modify the system." There's problems in steroidal use causing increase potency as well as duration of the medication as ONE example.
Putting it in very simple English: Cannabis can cause other drugs you are taken to be stronger and to last longer in the system. If you are taken a sedative (like Clonopin can be, opioids, etc ), the effects of your drugs can be dangerous because the dosage now has been exponentially increased and can cause severe respiration problems (slowing of the heart and lungs to the point you need emergency care). With other drug interactions with P450 issues can include liver damage.
With blood thinners it's a huge issue: From the NIH: "Initiation of cytochrome P-450 (CYP)-inducing anticonvulsant medications during warfarin therapy may decrease anticoagulant effect and necessitate frequent warfarin dose adjustments to maintain therapeutic response measured by the international normalized ratio (INR) ."
Topical cremes that have CBD with some THC involvement, is just not understood well enough. They want to cite the fact that it is dermal so therefore it's not being absorbed into the blood stream, but that does not help us to understand drug interactions that could be dangerous. Citing Harvard School of Medicine that although the topical can involve the liver, so little of us is being utilized, that they THINK it is safer…frankly, they don't know. By looking at Pro Cannabis sites that involve Tel Aviv studies would give you a better idea of what is safe and useable, over hype.
Personally having studied this stuff ad nauseam for my own needs, I found that I would be extremely concerned when taking cannabis of any stripe with steroids, blood thinners, Antidepressants, or sedatives simply because the impact can be seriously harmful. And I am a PRO CANNABIS user.
If you need further guidelines i would suggest a few places to ask your questions: Access for Safe Cannabis Foundation, Realm of Caring (for Dravet's and Cancer patients), Project CBD, the database Leafly, Hemp Round Table (lobbyist group), NORML, for clearer understanding of Cannabis. J Aviarm out of Israel, might give you better leads. All I know is this: Cannabis is a powerful herbal plant. Plants of any kind interact with other allopathic drugs. Taking any herbal formulae needs to be understood that it is medicinal; cannabis is no exception to the rule here. Finding the right information is crucial: While I normally do not suggest Healthline in general, this seems to be the simplest answer to the problem:
https://www.healthline.com/health/cbd-and-drug-interactions-what-you-need-to-know#interactions
This link explains Enzyme 450 also with using Grapefruit and other citrus interactions with medication.
So, does the cream have any interaction with meds? How is the cream removed from your body???
Thanks for the video; I am a heart patient, on statins and Toprol XL, but am also on Clonopin, but have been approved for CBD (MMJ). After viewing your video, I am very concerned about the drug interactions with a CBD product.
Thank you for this valuable information. I’m currently taking a blood thinner, Xarelto, which is problematic with CBD.
Excellent ! Thank you very much.
I just had a seizure Jan 1 , I have seizure medication but when I asked my primary if I can take CBD he said yes . So your saying it can react with my medication ?
Wow! This is so interesting! Thank you so much for doing this video! I had no idea.
If it isn't USDA approved don't buy it! Research first!
Thank you!
Wow I didn’t know this!! Crazy!