What Are Alt Cannabinoids? Here’s What Experts Say

Most Popular Alt Cannabinoids

Delta-0

TL;DR: Alt cannabinoid with possible (though often debated) psychedelic effects. 

Also known as THC-O or THC acetate, delta-0 is a semi-synthetic cannabinoid derived from the hemp compound delta-8 (3). 

According to a 2023 research article, delta-0 may produce low or moderate changes in cognitive function, such as an altered sense of time, difficulties concentrating, and hallucinations (3).

Side effects? Aside from the psychological effects of delta-0, users may also experience nausea, vomiting, muscle weakness, and gastrointestinal problems (4).

Delta-8

TL;DR: Diet weed? Sort of. 

Delta-8 tetrahydrocannabinol, or delta-8 THC, is a psychoactive compound found in the Cannabis sativa plant. While it is naturally found in small amounts of the hemp plant, most of the alt cannabinoid available is synthesized by converting hemp-derived CBD into delta-8 (5). It’s popular, widely available, and provides what many describe as a milder high than a traditional marijuana high.

“Delta-8 tetrahydrocannabinol is one of the most popular alt cannabinoids on the market,” Szymanowski says. “Delta-8 has a double bond between the 8th and 9th carbon.”

Side effects? The U.S. Food and Drug Administration (FDA) reports that delta-8 may cause hallucinations, vomiting, tremors, anxiety, dizziness, confusion, and loss of consciousness (5). 

Delta-9 THC

TL;DR: Your classic THC high. 

“Delta-9 is regarded as the primary intoxicating cannabinoid in the cannabis plant,” Szymanowski says. “The double bond in Delta-9 is between the 9th and 10th carbon.”

Delta-9 tetrahydrocannabinol is the primary psychoactive component of Cannabis sativa. Like delta-8, there’s not a significant amount of delta-9 in the hemp plant, so most of this alt cannabinoid available for sale has been synthesized from CBD (6).

Side effects? Research reveals that delta-9 may cause disconnected thoughts, delusions, hallucinations, panic reactions, and alarming changes in perception. The long-term effects of this alternative cannabinoid on a person’s cognitive function are unknown (7).